USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: GDIR1_HUMAN USC-OGP 2-DE database:  GDIR1_HUMAN GDIR1_HUMAN General information about the entry View entry in simple text format Entry name GDIR1_HUMAN Primary accession number P52565 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Rho GDP-dissociation inhibitor 1; Short=Rho GDI 1; AltName: Full=Rho-GDI alpha;. Gene name Name=ARHGDIA Synonyms=GDIA1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0188: pI=5.00; Mw=25675 SPOT OGP-0196: pI=5.00; Mw=25121 SPOT OGP-0198: pI=4.93; Mw=24929 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1275: pI=5.05; Mw=27445 SPOT OGP-1278: pI=5.09; Mw=26938 Cross-references UniProtKB/Swiss-Prot P52565; GDIR1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name GDIR1_HUMAN Primary accession number P52565 Secondary accession number(s) A8MXW0 B2R5X1 B4DDD3 B4DUV9 Q6IBM5 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  February 15, 2017 (version 172) Name and origin of the protein Description RecName: Full=Rho GDP-dissociation inhibitor 1; Short=Rho GDI 1; AltName: Full=Rho-GDI alpha; Gene name Name=ARHGDIA Synonyms=GDIA1 Encoded on Name=ARHGDIA; Synonyms=GDIA1 Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; GTPase activation; Isopeptide bond; Phosphoprotein; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X69550; CAA49281.1; -; mRNA EMBL D13989; BAA03096.1; -; mRNA EMBL M97579; AAA36566.1; -; mRNA EMBL X63863; CAA45344.1; -; Genomic_DNA EMBL AK300816; BAG62471.1; -; mRNA EMBL AK312347; BAG35268.1; -; mRNA EMBL AF498926; AAM21074.1; -; mRNA EMBL BT006884; AAP35530.1; -; mRNA EMBL CR456777; CAG33058.1; -; mRNA EMBL AC145207; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471099; EAW89697.1; -; Genomic_DNA EMBL BC005851; AAH05851.1; -; mRNA EMBL BC005875; AAH05875.1; -; mRNA EMBL BC008701; AAH08701.1; -; mRNA EMBL BC009759; AAH09759.1; -; mRNA EMBL BC016031; AAH16031.1; -; mRNA EMBL BC016185; AAH16185.1; -; mRNA EMBL BC024258; AAH24258.1; -; mRNA EMBL BC027730; AAH27730.1; -; mRNA EMBL BC075827; AAH75827.1; -; mRNA EMBL BC106044; AAI06045.1; -; mRNA CCDS CCDS11788.1; -. [P52565-1]; . CCDS CCDS58609.1; -. [P52565-2]; . PIR I38156; I38156; . RefSeq NP_001172006.1; NM_001185077.2. [P52565-1]; . RefSeq NP_001172007.1; NM_001185078.2. [P52565-2]; . RefSeq NP_001288169.1; NM_001301240.1; . RefSeq NP_001288170.1; NM_001301241.1; . RefSeq NP_001288171.1; NM_001301242.1; . RefSeq NP_001288172.1; NM_001301243.1; . RefSeq NP_004300.1; NM_004309.5. [P52565-1]; . UniGene Hs.159161; -; . UniGene Hs.599508; -; . UniGene Hs.728006; -; . PDB 1CC0; X-ray; 5.00 A; E/F=1-204 PDB 1FSO; X-ray; 2.00 A; A=67-204 PDB 1FST; X-ray; 2.70 A; A/B=24-204 PDB 1FT0; X-ray; 2.60 A; A/B=67-204 PDB 1FT3; X-ray; 2.80 A; A/B=67-204 PDB 1HH4; X-ray; 2.70 A; D/E=1-204 PDB 1KMT; X-ray; 1.30 A; A/B=67-204 PDB 1QVY; X-ray; 1.60 A; A/B/C/D=67-204 PDB 1RHO; X-ray; 2.50 A; A/B/C=59-203 PDB 2BXW; X-ray; 2.40 A; A/B=67-204 PDB 2JHS; X-ray; 1.95 A; A=67-202 PDB 2JHT; X-ray; 1.88 A; A/B/C/D=67-202 PDB 2JHU; X-ray; 1.65 A; A/B=67-202 PDB 2JHV; X-ray; 2.07 A; A/B/C/D/E/F=67-202 PDB 2JHW; X-ray; 2.50 A; A/B=67-202 PDB 2JHX; X-ray; 1.60 A; A/B=67-202 PDB 2JHY; X-ray; 1.90 A; A=67-202 PDB 2JHZ; X-ray; 2.20 A; A/B=67-202 PDB 2JI0; X-ray; 2.10 A; A=67-202 PDB 2N80; NMR; -; B=31-204 PDBsum 1CC0; -; . PDBsum 1FSO; -; . PDBsum 1FST; -; . PDBsum 1FT0; -; . PDBsum 1FT3; -; . PDBsum 1HH4; -; . PDBsum 1KMT; -; . PDBsum 1QVY; -; . PDBsum 1RHO; -; . PDBsum 2BXW; -; . PDBsum 2JHS; -; . PDBsum 2JHT; -; . PDBsum 2JHU; -; . PDBsum 2JHV; -; . PDBsum 2JHW; -; . PDBsum 2JHX; -; . PDBsum 2JHY; -; . PDBsum 2JHZ; -; . PDBsum 2JI0; -; . PDBsum 2N80; -; . ProteinModelPortal P52565; -; . SMR P52565; -; . BioGrid 106889; 91; . IntAct P52565; 38; . MINT MINT-93856; -; . STRING 9606.ENSP00000269321; -; . BindingDB P52565; -; . ChEMBL CHEMBL3638327; -; . iPTMnet P52565; -; . PhosphoSitePlus P52565; -; . SwissPalm P52565; -; . BioMuta ARHGDIA; -; . DMDM 1707892; -; . DOSAC-COBS-2DPAGE P52565; -; . OGP P52565; -; . REPRODUCTION-2DPAGE IPI00003815; -; . EPD P52565; -; . PaxDb P52565; -; . PeptideAtlas P52565; -; . PRIDE P52565; -; . TopDownProteomics P52565-1; -. [P52565-1]; . DNASU 396; -; . Ensembl ENST00000269321; ENSP00000269321; ENSG00000141522. [P52565-1]; . Ensembl ENST00000400721; ENSP00000383556; ENSG00000141522. [P52565-2]; . Ensembl ENST00000541078; ENSP00000441348; ENSG00000141522. [P52565-1]; . Ensembl ENST00000580685; ENSP00000464205; ENSG00000141522. [P52565-1]; . GeneID 396; -; . KEGG hsa:396; -; . UCSC uc021ufg.2; human. [P52565-1]; . CTD 396; -; . DisGeNET 396; -; . GeneCards ARHGDIA; -; . HGNC HGNC:678; ARHGDIA; . HPA CAB010005; -; . HPA HPA021407; -; . MalaCards ARHGDIA; -; . MIM 601925; gene; . MIM 615244; phenotype; . neXtProt NX_P52565; -; . OpenTargets ENSG00000141522; -; . Orphanet 93217; Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis; . PharmGKB PA24963; -; . eggNOG KOG3205; Eukaryota; . eggNOG ENOG4111K44; LUCA; . GeneTree ENSGT00390000006233; -; . HOGENOM HOG000175765; -; . HOVERGEN HBG000206; -; . InParanoid P52565; -; . KO K12462; -; . OMA QMSESSI; -; . PhylomeDB P52565; -; . TreeFam TF105387; -; . Reactome R-HSA-193634; Axonal growth inhibition (RHOA activation); . Reactome R-HSA-194840; Rho GTPase cycle; . Reactome R-HSA-209563; Axonal growth stimulation; . SIGNOR P52565; -; . EvolutionaryTrace P52565; -; . GeneWiki ARHGDIA; -; . GenomeRNAi 396; -; . PRO PR:P52565; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000141522; -; . CleanEx HS_ARHGDIA; -; . ExpressionAtlas P52565; baseline and differential; . Genevisible P52565; HS; . GO GO:0005856; C:cytoskeleton; TAS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW; . GO GO:0005094; F:Rho GDP-dissociation inhibitor activity; TAS:ProtInc; . GO GO:0006928; P:movement of cell or subcellular component; TAS:UniProtKB; . GO GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB; . GO GO:0050771; P:negative regulation of axonogenesis; TAS:Reactome; . GO GO:0007162; P:negative regulation of cell adhesion; TAS:ProtInc; . GO GO:0050772; P:positive regulation of axonogenesis; TAS:Reactome; . GO GO:2000249; P:regulation of actin cytoskeleton reorganization; IMP:UniProtKB; . GO GO:0035023; P:regulation of Rho protein signal transduction; IMP:UniProtKB; . GO GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome; . GO GO:0071526; P:semaphorin-plexin signaling pathway; ISS:UniProtKB; . Gene3D 2.70.50.30; -; 1; . InterPro IPR014756; Ig_E-set; . InterPro IPR000406; Rho_GDI; . InterPro IPR024792; RhoGDI_domain; . PANTHER PTHR10980; PTHR10980; 1; . Pfam PF02115; Rho_GDI; 1; . PRINTS PR00492; RHOGDI; . SUPFAM SSF81296; SSF81296; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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